Enhanced with Personalized RPRP®
A medical-grade procedure that physically removes harmful substances from your plasma and replaces it with purified solution — designed specifically around your biology, your diagnosis, and your health goals.
Serving San Ramon · Turlock · Kailua Kona, HI
(and
patients nationwide via consultation)
Here’s what most doctors won’t tell you:
Sometimes the inflammatory triggers keeping you sick aren’t hiding in your gut, your food, or your environment. They’re circulating in your bloodstream and your body simply cannot clear them on its own.
That’s exactly what Therapeutic Plasma Exchange was designed to address.
Think of your blood as a river. In autoimmune disease, chronic systemic inflammation, and accelerated biological aging, that river becomes polluted carrying antibodies attacking your own tissues, inflammatory cytokines driving widespread damage, and accumulated biological waste your body cannot clear alone.
No medication can clean that river. Therapeutic Plasma Exchange can.
During the procedure, your blood passes through a specialized medical device that separates your plasma (the liquid component carrying the harmful substances) from your healthy blood cells. The old plasma is discarded. Your blood cells are then recombined with fresh albumin solution and returned to your body.
At The Real Gut Doctor, we enhance this clinically proven, hospital-grade procedure with our proprietary RPRP® (Regenerative Plasma Renewal Protocol) — a personalized regenerative medicine system built around your specific inflammatory profile, diagnosis, and healing goals.
“TPE physically removes the contaminated portion of your plasma and replaces it with a fresh, medical-grade solution taking out the substances that are actively keeping you sick, at the source.”
Blood is gently drawn from your arm through a small, standard needle no surgery required.
A specialized apheresis device separates your plasma from your healthy blood cells.
The old plasma containing inflammatory antibodies, cytokines, and toxins is permanently removed and discarded.
Your blood cells are recombined with fresh, medical-grade albumin solution and returned to your body.
Immediately following your exchange, your customized Regenerative Plasma Renewal Protocol is applied optimizing your body’s healing and regenerative response.
| Approach | Standard Protocol | TPE + RPRP® |
|---|---|---|
| Methodology | Suppress symptoms | Remove root cause |
| Mechanism | Medication / lifestyle | Physical plasma filtration |
| Evidence | Variable | FDA-cleared, hospital use |
| Personalization | Generic protocols | Custom biological profiling |
| Post-Care | None | RPRP® regenerative system |
| Measurability | Subjective | Lab-verified reductions |
This isn’t another treatment that manages your symptoms.
TPE + RPRP® gives your body the clean slate it needs to finally
heal.
As neuroinflammation decreases, patients report dramatic improvements in brain fog and cognitive performance.
When your immune system stops fighting a constant burden, your energy returns to you fully.
Measurable reductions in autoimmune flare frequency across Hashimoto’s, Rheumatoid Arthritis, and Lupus.
Clearing systemic inflammatory load translates to real reductions in joint and whole-body pain.
As the nervous system calms, sleep architecture improves and mood stabilizes.
Progress tracked via comprehensive testing showing lab-verified reductions in CRP, ESR, and autoantibodies.
No two protocols are identical. Dr. Mark designs your post-exchange regenerative treatment around your specific diagnosis, inflammatory profile, and long-term health objectives. It’s not just feeling better—it’s getting your life back securely.
Our patients don’t only report fewer symptoms. They report returning to who they were—the energy to pursue what they love, the clarity to lead, and the vitality to live fully rather than just manage illness.
Schedule Your Personalized TPE Consultation →“My brain fog was so severe I considered early retirement. After my TPE protocol with Dr. Mark, my mental sharpness returned entirely. I have my life back.”
“Years of autoimmune flares managed with harsh medications. The RPRP protocol lowered my antibody markers dramatically. The lab work speaks for itself, but feeling normal again speaks volumes louder.”
Dr. Mark isn’t just another physician offering plasma exchange. He is one of the most credentialed regenerative and functional medicine physicians in the United States.
Functional Medicine, Regenerative Medicine, Metabolic Medicine, Internal Medicine, and Gastroenterology.
Including Stem Cell Fellowships, Energy & Longevity Medicine, Peptide Protocols, Medical Acupuncture, and TCM Modalities.
Beyond TPE + RPRP®, Dr. Mark offers a comprehensive suite of advanced regenerative treatments, meaning your care is systematically layered across multiple biological modalities:
While most doctors respond to treatment-resistant inflammation by adding another medication, Dr. Mark responded by asking a different question: What if we removed what’s keeping them sick, instead of just suppressing how it feels?
That question led to the development of RPRP®.
“When conventional medicine tells you to ‘just manage your symptoms,’ I see an opportunity to remove the very substances causing those symptoms. TPE isn’t suppression, it’s elimination. We’re physically taking the inflammatory triggers out of your body.”
Dr. Mark and Dr. Frances Mark, Pharm.D. developed the protocol because standard TPE stops at the mechanical exchange itself.
RPRP® immediately applies a personalized regenerative signal post-exchange to accelerate immune stabilization—closing the gap standard hospitals overlook.
Every RPRP® protocol is customized. No two patients receive the same plan.
Yes. TPE is a well-established, FDA-cleared medical procedure performed safely in hospital and clinical settings for decades. At The Real Gut Doctor, every session is administered by our specialized clinical team under the direct supervision of Dr. Mark.
RPRP® is most appropriate for adults who have not achieved satisfactory results through conventional treatments — including those with autoimmune conditions (Hashimoto’s, RA, Lupus, MS), lab-confirmed chronic systemic inflammation, chronic fatigue or brain fog, and adults over 40 pursuing biological age optimization or peak performance.
A typical RPRP® session takes between 2 and 3 hours, depending on the volume of plasma exchanged and the personalized post-exchange protocol applied.
This is determined individually. Before your first session, you will complete a comprehensive medical intake. Dr. Mark will review your full history, lab work, and medications to design a multi-session protocol tailored to your condition.
TPE for standard FDA-approved medical indications may carry some insurance coverage. The RPRP® regenerative protocol is typically a self-pay service. Our team will help clarify your coverage during your consultation.
Yes. Emerging longevity research indicates that replacing older, cytokine-rich plasma with fresh albumin solution dilutes pro-aging factors and creates a more favorable environment for cellular repair. Many of our RPRP® patients pursue the protocol specifically for biological age optimization.
Schedule your personalized TPE + RPRP® consultation with Dr. Jeffrey C.G. Mark today. Our team will review your history, discuss your goals, and determine whether TPE is the right next step for your healing.
Schedule Your Consultation →111 Deerwood Road,
Suite 168
San Ramon, CA 94583
📞 (925) 736-9828
701 E Olive
Ave
Turlock, CA 95380
📞 (209) 668-6020
74-5577 Palani Road,
Suite 3310
Kailua Kona, HI 96740
📞 (808) 756-9189
Telemedicine and out-of-state consultations available.
